Two Rivers National Wildlife Refuge
- Address: 364 Wildlife Conservation Rd
- Vicinity: SE of Brussels, IL
- US County of Calhoun County in Illinois
Two Rivers National Wildlife Refuge is a protected river environment for migratory birds located between the Mississippi River and the Illinois River in the central part of the US state of Illinois. The refuge encompasses thousands of acres of riverine and floodplain lands, including bottomland forests, wetlands, open water, and prairies. These diverse habitats support a wide range of wildlife, including nearly 300 bird species, as well as flora such as the aster, a federally threatened plant species. — AsNotedIn