The Winona Bridge is a series of structures that span the Mississippi River in the United States between Winona, Minnesota, and Buffalo, Wisconsin.

The Main Channel Bridge, actually a pair of bridges, carries Minnesota State Highway 43 across the main channel of the Mississippi River from the south bank in central Winona to Latsch Island. The pair of structures that constitute the Winona Bridge south of Latsch Island include a steel cantilever through truss bridge and a concrete box girder bridge. The North Channel Bridge carries MN-43, which continues as Wisconsin Highway 54, from Latsch Island to Buffalo, Wisconsin.

Just south of the Winona Bridge on each side of Latsch Island are remaining sections of the CNW Winona Railroad Bridge. Further east, near the end of E 3rd Street in Winona, is the site of the 1891 BN Winona Railroad Crossing bridge. Demolished in October 1990 after a fire, the largest remains of this crossing are two built up rail ends. The Winona Bridge Railway was incorporated by the Chicago, Burlington and Quincy Railroad and the Green Bay, Winona, and Saint Paul Railroad to facilitate the building of a rail bridge at Winona. The total trackage of this short line railroad was just over one mile, consisting of the bridge and the approach lines. - AsNotedIn